ENCEFALOPATIA DE HASHIMOTO PDF

Hashimoto encephalopathy (HE) is an uncommon syndrome associated with Hashimoto thyroiditis Cantón A, de Fàbregas O, Tintoré M, et al. Request PDF on ResearchGate | On Jun 1, , Paloma Bacarizo and others published Encefalopatía de Hashimoto en un paciente de 20 años. CLINICAL/SCIENTIFIC NOTE. Hashimoto’s encephalopathy. Encefalite de Hashimoto. Renata Telles Rudge de AquinoI; Eduardo Genaro MutarelliII.

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J Neurol Sci ; Encephalomyelitis Acute disseminated Myalgic Meningoencephalitis.

Hashimoto’s encephalopathy with clinical features similar to those of Creutzfeldt-Jakob disease

The rest of the physical examination was normal. A good response to corticoteroids is typical 2,4.

It is associated with Hashimoto’s thyroiditis. We describe the case of a patient with Hashimoto’s encephalopathy who showed clinical manifestations similar to those of Creutzfeldt-Jakob disease.

Hashimoto’s encephalopathy

At admission, she was sleepy, disoriented, showing myoclonus, paratonia on the back of the head and arms, her deep reflexes were symmetrical with plantar flexion response and suction and grasping reflexes were present. It presents with acute or sub-acute encephalopathy, tremor, myoclonus, ataxia, fits, psychosis or stroke like events, progressive or relapsing, high titres of anti-thyroid antibodies but independent of thyroid function 2,4, The presence of antithyroglobulin encfalopatia Ac-anti-Tg was not detected.

It is recommended to reduce the dose of steroids over several months. HE occur predominantly in women 4: Hashimoto’s encephalitis HEencephalitis which responds to steroids and is associated with auto-immune thyroiditis, was described by Brain et al.

Little is known about the pathogenesis. The significance of classifying encephalopathies under the term HE will be determined in the future hashijoto the relevance of the role of antithyroid antibodies is demonstrated or dismissed by more detailed experimental and immunopathological studies. The dose of thyroxine was reduced to mcg.

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Encefalopatia de Hashimoto

Retrieved from ” https: This report emphasizes the importance of a differential diagnosis between the two pathologies. Received 6 Novemberreceived in final form 30 March In an epidemiological study made by Seipelt et al.

Now, two years later, she is well and is on prednisolone 2. Proteomic analysis of human brain identifies alpha-enolase as a novel autoantigen in Hashimoto’s encephalopathy. The first case of HE was described by Brain et al.

Rarity of encephalopathy associated with autoimmune thyroiditis: Hepato-toxicity led to the interruption of azathioprine in this case. The correlation between anti-TPO and initial clinical progress observed was seen in some cases 8. The majority of patients return to their normal neurological state.

There are EEG changes in most cases, mainly general slowing 2,8. Japan, and Depannient of Anatomy and Biology. The mechanism of pathogenesis is not known but it has been hypothesized to be an autoimmune disorder, similar to Hashimoto’s thyroiditis as its name suggests.

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Hashimoto’s encephalopathy – Wikipedia

Isolated angiitis of the CNS associated with Hashimoto’s disease. Episodes of sinus tachycardia of bpm followed, with normal cardiac investigations.

Alopecia is associated with polyglandular autoimmunity. MRI and cerebral angiography are normal in the majority of cases hadhimoto. The prevalence has been estimated to be 2. Very little is known about the pathology of Hashimoto’s encephalopathy.

Long-term treatment of Hashimoto’s encephalopathy.

For many other patients, the condition may result in ongoing problems with a variety of manifestations, often confusing clinicians due to the diffuse nature of symptoms. There must be suspicion of HE patients with diverse neuro-psychiatric manifestations and a history of Hashimoto’s thyroiditis. Normotensive, pulse bpm, she had universal alopecia, cyanosis and pale alternating in the extremities, growing nails of the right hand and scars on her back and face. In the first two weeks, a considerable improvement in level of consciousness and myoclonus was observed.

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Since that time, research has expanded and numerous cases are being reported by scientists around the world, suggesting that this rare condition is likely to have been significantly undiagnosed in the past.

In this case, the Hashimoto’s encephalopathy diagnosis was made based on the exclusion of other toxic-metabolic encephalopathic and neurological diseases of infectious or vascular origin, and on the detection of high concentrations of anti-TPO antibodies.

The responsiveness of HE to steroids or other therapies such as plasmapheresis supports the hypothesis that this is a disorder that involves immune pathogenic mechanisms. Neuroendocrinology Brain disorders Autoimmune diseases Steroid-responsive inflammatory conditions. Symptoms sometimes resolve themselves within days to weeks, leaving a patient undiagnosed. Anti-thyroperoxidase antibodies anti-TPO was 1. Views Read Edit View history.

She had a 2 years history of feeling progressively tired, insomnia, cramps, tremors, arthralgia, paraethesia in her hands and back pain. The most common findings are diffuse or generalized slowing or frontal intermittent rhythmic delta activity. A relapsing encephalopathy occurring in association with Hashimoto’s thyroiditisenefalopatia high titers of anti-thyroid antibodies.